Collaborations

Stephen J. Royle (Full Professor, Centre for Mechanochemical Cell Biology, University of Warwick, UK)

Keywords: membrane trafficking, image analysis, cell division

Thematic

Steve is interested in cell biology at the molecular level. His lab is focussed on understanding membrane traffic and mitosis primarily using quantitative imaging approaches. To investigate these processes, Steve's lab has developed a number of genetic tools, including "hot-wired endocytosis" which enables endocytosis to be triggered on-demand.

Franck Carreiras (Full Professor CY Cergy Paris University)

Key words : Cell Biology, Cell-Matrix interactions, Tumoral microenvironment

Thematic

His recruitment at Cergy Pontoise allowed him to set up within the University a long-lasting theme concerning the influence of the matrix microenvironment on the tumoral dissemination. Since his nomination as leader of the MEC-uP group he continues this work on the tumoral microenvironment and the metastatic dissemination while diversifying his projects according to the knowledge of each members of his group (cellular ageing, tissue repair, surfaces functionalization). The characterization of the matrix microenvironment and its regulating impact on cellular activities stays at the center of his research.

Olivier Gallet (Full Professor CY Cergy Paris University)

Key words : Cell adhesion proteins, ECM dynamics, Glycosylations, lectins, plant wall, biofunctionalization, cell adhesion, matrix engineering, Biological traces and forensic sciences, Cellular behaviour and adaptation to environmental parameters.

Thematic

I-Universality of cell adhesion proteins

Purification and characterization of matrix proteins (Fibronectin and vitronectin) in animal tissues and identification of homologues in plant walls. Study of the impact of glycosylations on the conformation of cell adhesion proteins and their recognition by animal and plant cells. Biofunctionalization of hybrid materials and studies of protein conformations onto the surface of materials alone or in interaction with cells

II- Characterization of multifunctional heterologous protein polymers

Role in immunity and adaptation to environmental stress. Study of the involvement of glycosylation sequences in the formation of protein polymers in association with lectins: Case of fibronectin and vitronectin interactions of blood plasma with circulating lectins (Mannose Binding proteins and Collectins).

III- Cellular behaviour –Biological traces and footprint of life- adaptation of life to environmental parameters

Study of the biological trace and its persistence in time in different mimetic environments of criminal scenes. Cellular behaviour on different interfaces. Research and discrimination of human cell trace markers.

Behaviour of plants and human cells submitted to the variations of the physicochemical parameters of the environment as surface chemical composition, biomolecular surfaces or intefaces, surface topography and sound environment.

Carole Aimé (ENS Chimie Paris)

My research interest is directed towards the multidimensional description and understanding of biological systems. We develop microfluidics-based biosystems to catch and reproduce biological features: hierarchical organization, function and dynamics. This is based on expertise in chemical-physics of biomolecules and biopolymers self-assembly for biomaterials engineering and expertise in nano/microfabrication for biosystems engineering at the Department of Chemistry at ENS (Microfluidics group).

Alexandra Naba is an Associate Professor in the Department of Physiology and Biophysics at the University of Illinois Chicago. She is also an affiliate member of the Richard & Loan Hill Department of Bioengineering, a member of the University of Illinois Cancer Center, and a fellow of the UIC Honors College.

Alexandra, a Parisian native, received her Ph.D. from the Curie Institute in Paris, France, where she studied the role of the membrane-cytoskeleton linker, ezrin, in normal and tumor cell adhesion in the laboratory of Pr. Daniel Louvard under the supervision of Dr. Monique Arpin.

For her postdoctoral training, Alexandra joined the laboratory of Dr. Richard Hynes at the Koch Institute for Integrative Cancer Research at the Massachusetts Institute of Technology (MIT), where she led a project aimed at understanding the role of the extracellular matrix (ECM) in tumor progression. The ECM is a requirement and defining characteristic of metazoan life. A handful of ECM molecules are known to make critical contributions to disease processes, but technical limitations have prevented a comprehensive analysis of this critical family of proteins. At MIT, Alexandra overcame these barriers and developed novel proteomic and bioinformatic methods to study the molecular composition of the ECM, pioneering the field of "matrisomics". Her work demonstrated striking differences in the matrisome of tumors of different metastatic potential and showed that distinct sets of ECM proteins could predict the metastatic potential of primary tumors. More recently, Alexandra founded the Matrisome Project and MatrisomeDB, two resources designed to disseminate tools and data on the ECM to advance ECM research.

Laurent leads the biointerfaces group is interested in understanding how cells interact with their physical environment by developing interdisciplinary approaches that combine cell biology, biophysics and modelling. They investigate the mechanisms that drive curvature sensing by cells and tissues. They also develop biomimetic micro-environments, bio-derived microsystems, bioactive and biocidal materials, at the interface between biology and material sciences.

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