Key words : Cell adhesion proteins, ECM dynamics, Glycosylations, lectins, plant wall, biofunctionalization, cell adhesion, matrix engineering, Biological traces and forensic sciences, Cellular behaviour and adaptation to environmental parameters.
I-Universality of cell adhesion proteins
Purification and characterization of matrix proteins (Fibronectin and vitronectin) in animal tissues and identification of homologues in plant walls. Study of the impact of glycosylations on the conformation of cell adhesion proteins and their recognition by animal and plant cells. Biofunctionalization of hybrid materials and studies of protein conformations onto the surface of materials alone or in interaction with cells
II- Characterization of multifunctional heterologous protein polymers
Role in immunity and adaptation to environmental stress. Study of the involvement of glycosylation sequences in the formation of protein polymers in association with lectins: Case of fibronectin and vitronectin interactions of blood plasma with circulating lectins (Mannose Binding proteins and Collectins).
III- Cellular behaviour –Biological traces and footprint of life- adaptation of life to environmental parameters
Study of the biological trace and its persistence in time in different mimetic environments of criminal scenes. Cellular behaviour on different interfaces. Research and discrimination of human cell trace markers.
Behaviour of plants and human cells submitted to the variations of the physicochemical parameters of the environment as surface chemical composition, biomolecular surfaces or intefaces, surface topography and sound environment.